When former Green Beret John Rambo is harassed by local law enforcement and arrested for vagrancy, the Vietnam vet snaps, runs for the hills and rat-a-tat-tats his way into the action-movie hall of fame. Hounded by a relentless sheriff, Rambo employs heavy-handed guerilla tactics to shake the cops off his tail.
Combat has taken its toll on Rambo, but he's finally begun to find inner peace in a monastery. When Rambo's friend and mentor Col. Trautman asks for his help on a top secret mission to Afghanistan, Rambo declines but must reconsider when Trautman is captured.
When governments fail to act on behalf of captive missionaries, ex-Green Beret John James Rambo sets aside his peaceful existence along the Salween River in a war-torn region of Thailand to take action. Although he's still haunted by violent memories of his time as a U.S. soldier during the Vietnam War, Rambo can hardly turn his back on the aid workers who so desperately need his help.
After fighting his demons for decades, John Rambo now lives in peace on his family ranch in Arizona, but his rest is interrupted when Gabriela, the granddaughter of his housekeeper Maria, disappears after crossing the border into Mexico to meet her biological father. Rambo, who has become a true father figure for Gabriela over the years, undertakes a desperate and dangerous journey to find her.