Daryll Deever is a janitor in an office building in New York, and a big fan of TV news reporter, Tony Sokolow. When a rich man is murdered in Daryll's building, Tony comes to cover the story and Daryll introduces himself to her. Thinking he may know something about the crime, Tony pursues him, and in order to keep seeing her, he pretends that he does. As the two of them play this game, the killers are watching, assuming that Daryll and Tony both know more about the crime than they do.
James, a new speech teacher at a school for the deaf, falls for Sarah, a pupil who decided to stay on at the school rather than venture into the big bad world. She shuns him at first, refusing to read his lips and only using signs.
After the death of his son, travel writer Macon Leary seems to be sleep walking through life. Macon's wife is having similar problems. They separate, and Macon meets a strange, outgoing woman who brings him 'back down to earth', but his wife soon thinks their marriage is still worth another try.
Writer Paul Benjamin is nearly hit by a bus when he leaves Auggie Wren's smoke shop. Stranger Rashid Cole saves his life, and soon middle-aged Paul tells homeless Rashid that he wouldn't mind a short-term housemate. Still grieving over his wife's murder, Paul is moved by both Rashid's quest to reconnect with his father and Auggie's discovery that a woman who might be his daughter is about to give birth.
The prospects for continuing life on Earth in the year 2058 are grim. So the Robinsons are launched into space to colonize Alpha Prime, the only other inhabitable planet in the galaxy. But when a stowaway sabotages the mission, the Robinsons find themselves hurtling through uncharted space.