In this modern day version of Shakespeare's Macbeth, a hitman heeds a spiritualist's prophesies that he will rise to the head of his family. He starts his ascension by clandestinely executing the heads of the family and casting the blame on others. However, with power comes consequences that are also predicted by the seer.\
Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.
Two victims of traumatized childhoods become lovers and serial murderers irresponsibly glorified by the mass media.
A botched robbery indicates a police informant, and the pressure mounts in the aftermath at a warehouse. Crime begets violence as the survivors -- veteran Mr. White, newcomer Mr. Orange, psychopathic parolee Mr. Blonde, bickering weasel Mr. Pink and Nice Guy Eddie -- unravel.
Babe, fresh from his victory in the sheepherding contest, returns to Farmer Hoggett's farm, but after Farmer Hoggett is injured and unable to work, Babe has to go to the big city to save the farm.