Set during the Cold War, the Soviets - led by sword-wielding Irina Spalko - are in search of a crystal skull which has supernatural powers related to a mystical Lost City of Gold. After being captured and then escaping from them, Indy is coerced to head to Peru at the behest of a young man whose friend - and Indy's colleague - Professor Oxley has been captured for his knowledge of the skull's whereabouts.
Iconoclastic, take-no-prisoners cop John McClane, finds himself for the first time on foreign soil after traveling to Moscow to help his wayward son Jack - unaware that Jack is really a highly-trained CIA operative out to stop a nuclear weapons heist. With the Russian underworld in pursuit, and battling a countdown to war, the two McClanes discover that their opposing methods make them unstoppable heroes.
Stripped of his medical license after performing an operation while high on amphetamines, famed LA surgeon Dr Eugene Sands abandons his former life only to find himself crossing paths with Raymond Blossom, an infamous counterfeiter. Employed as a "gun-shot doctor" when Raymond's associates cannot risk visiting a hospital, Eugene is lured deep into the criminal world and becomes entangled with his boss's girlfriend.