The Newton family live in their comfortable home, but there seems to something missing. This "hole" is filled by a small puppy, who walks into their home and their lives. Beethoven, as he is named, grows into a giant of a dog... a St Bernard. Doctor Varnick, the local vet has a secret and horrible sideline, which requires lots of dogs for experiments. Beethoven is on the bad doctor's list.
A small suburban town receives a visit from a castaway unfinished science experiment named Edward.
A male prison escapee heads for his hidden loot, electronically attached to a female prisoner.
Two victims of traumatized childhoods become lovers and serial murderers irresponsibly glorified by the mass media.