Amanda's deathbed request to her son, John, was for him to destroy all the lab notes etc. from her last experiment. She also blurts out he had a brother. At the funeral John meets Melissa, who claims to be his mothers biggest fan. Together with some of John's friends they go to Amanda's house, but none are prepared for what they find there.
A group of varied misfits (including a former prostitute/stripper and a bumbler who can't see more than 6 inches in front of his face) enter a school to become flight attendants. Somehow, the group makes it through to the final test: a cross-country flight.
A tough police sergeant's mother comes to visit him, and promptly starts trying to fix up his life, much to his embarrassment. For his birthday she buys him a machine gun out of the back of a van, and begins to further interfere with his job and love life, eventually helping him with a case he's on.