Veteran buttoned-down LAPD detective Roger Murtaugh is partnered with unhinged cop Martin Riggs, who -- distraught after his wife's death -- has a death wish and takes unnecessary risks with criminals at every turn. The odd couple embark on their first homicide investigation as partners, involving a young woman known to Murtaugh with ties to a drug and prostitution ring.
A tough Russian policeman is forced to partner up with a cocky Chicago police detective when he is sent to Chicago to apprehend a Georgian drug lord who killed his partner and fled the country.