Mike Sullivan works as a hit man for crime boss John Rooney. Sullivan views Rooney as a father figure, however after his son is witness to a killing, Mike Sullivan finds himself on the run in attempt to save the life of his son and at the same time looking for revenge on those who wronged him.
In 1839, the slave ship Amistad set sail from Cuba to America. During the long trip, Cinque leads the slaves in an unprecedented uprising. They are then held prisoner in Connecticut, and their release becomes the subject of heated debate. Freed slave Theodore Joadson wants Cinque and the others exonerated and recruits property lawyer Roger Baldwin to help his case. Eventually, John Quincy Adams also becomes an ally.