Novelist Paul Sheldon crashes his car on a snowy Colorado road. He is found by Annie Wilkes, the "number one fan" of Paul's heroine Misery Chastaine. Annie is also somewhat unstable, and Paul finds himself crippled, drugged and at her mercy.
A young kid from Kansas moves to New York to work on a magazine. He gets caught up in the world of drink and drugs, and starts a steady decline. The only hope is the cousin of one of his drinking partners, can she pull him through it ?
Marjorie Turner is suffocating. Her younger sister Jeanine has no ambition, and her 8 year marriage to Harry puts her in constant competition with his family (all doctors)..
When neighborhood kids begin vanishing, Jenny suspects her child psychologist husband, Carter, may be resuming the deranged experiments his father performed on Carter when he was young. Now, it falls to Jenny to unravel the mystery. And as more children disappear, she fears for her own child's safety.