Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon on the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.
A brain surgeon tries to end his unhappy marriage to spend more time with a disembodied brain.
Just before stubborn millionaire Edwina Cutwater dies, she asks her uptight lawyer, Roger Cobb, to amend her will so that her soul will pass to the young, vibrant Terry Hoskins – but the spiritual transference goes awry. Edwina enters Roger's body instead, forcing him to battle Edwina for control of his own being.
Private eye Philip Marlowe and his bride move to a desert town, where he uncovers a land scheme.