Amanda's deathbed request to her son, John, was for him to destroy all the lab notes etc. from her last experiment. She also blurts out he had a brother. At the funeral John meets Melissa, who claims to be his mothers biggest fan. Together with some of John's friends they go to Amanda's house, but none are prepared for what they find there.
FBI Agent Will Graham, who retired after catching Hannibal Lecktor, returns to duty to engage in a risky cat-and-mouse game with Lecktor to capture a new killer.
Three years after Steve Peterson's wife, Nina, was murdered in front of their 11 year old daughter Julie, she and his new girlfriend Sharon Martin are kidnapped by the same killer, the psychotic Artie Taggart. Imprisoning them in a bunker below Grand Central Station, he throws the police into a race against time to save the girls and catch the killer.
Chuck Nolan, a top international manager for FedEx, and Kelly, a Ph.D. student, are in love and heading towards marriage. Then Chuck's plane to Malaysia crashes at sea during a terrible storm. He's the only survivor, and finds himself marooned on a desolate island. With no way to escape, Chuck must find ways to survive in his new home.