Norman Bates is again released from the mental hospital he was placed in at the end of Psycho III after serving another few years and is apparently rehabiliated for the second time. Norman is now married to a young nurse named Connie and is expecting a child. However, Norman fears that the child will inherit his mental illness. Meanwhile, Fran Ambrose is a radio talk show host who is discussing the topic of matricide with guest Dr. Richmond, Norman's former psychologist. The radio station receives a call from Norman, who uses the alias "Ed" to tell his story.
A down-and-out private eye (Treat Williams) gets too close to the wife (Virginia Madsen) of a rich man (Richard Masur) soon found dead.
Ex-soldier Frank Brayker is the guardian of an ancient key that can unlock tremendous evil; the sinister Collector is a demon who wants the key so he can initiate the apocalypse. On the run from wicked mercenaries for almost 90 years, Brayker finally stops in at a boarding house in New Mexico where -- with the help of its residents -- he plans to face off against the Collector and his band of ghouls, preventing them from ever seizing the key.
In order to foil a terrorist plot, an FBI agent undergoes facial transplant surgery and assumes the identity of a criminal mastermind, who murdered his only son. The plan turns sour when the criminal wakes up prematurely and seeks revenge.
A mentally ill young woman finds her love in an eccentric man who models himself after Buster Keaton.