Four Harlem friends -- Bishop, Q, Steel and Raheem -- dabble in petty crime, but they decide to go big by knocking off a convenience store. Bishop, the magnetic leader of the group, has the gun. But Q has different aspirations. He wants to be a DJ and happens to have a gig the night of the robbery. Unfortunately for him, Bishop isn't willing to take no for answer in a game where everything's for keeps.
After a friend overdoses, Spoon and Stretch decide to kick their drug habits and attempt to enroll in a government detox program. Their efforts are hampered by seemingly endless red tape, as they are shuffled from one office to another while being chased by drug dealers and the police.
Two men in 1930s Mississippi become friends after being sentenced to life in prison together for a crime they did not commit.