When bachelor Walter Davis is set up with his sister-in-law's pretty cousin, Nadia Gates, a seemingly average blind date turns into a chaotic night on the town. Walter's brother, Ted, tells him not to let Nadia drink alcohol, but he dismisses the warning and her behaviour gets increasingly wild. Walter and Nadia's numerous incidents are made even worse as her former lover David relentlessly follows them around town.
Norman Bates is again released from the mental hospital he was placed in at the end of Psycho III after serving another few years and is apparently rehabiliated for the second time. Norman is now married to a young nurse named Connie and is expecting a child. However, Norman fears that the child will inherit his mental illness. Meanwhile, Fran Ambrose is a radio talk show host who is discussing the topic of matricide with guest Dr. Richmond, Norman's former psychologist. The radio station receives a call from Norman, who uses the alias "Ed" to tell his story.