A cross-country road race is based on an actual event, the Cannonball Baker Sea to Shining Sea Memorial Trophy Dash, organized by Brock Yates to protest the 55 mph speed limit then in effect in the U.S. The Cannonball was named for Erwin G. "Cannonball" Baker, who in the roaring 20's rode his motorcycle across the country. Many of the characters are based on ruses developed by real Cannonball racers over the several years that the event was run.
Undercover cop Doyle is working on a serial killer case that's left a trail of dead transvestites. Then, moonlighting as a private eye, Doyle and his girlfriend are hired by a rich young man to find his sister. The search leads to her mysterious uncle, and the possibility of becoming the killer's next victim.