The eccentric and childish Pee-wee Herman embarks on a big adventure when his beloved bicycle is stolen. Armed with information from a fortune-teller and a relentless obsession with his prized possession, Pee-wee encounters a host of odd characters and bizarre situations as he treks across the country to recover his bike.
After a young boy is almost runover by a maniac on a highway, a re-encounter and confrontation by the boy's father with the driver sets off conflicts with a carful of maniacs.