Set during the Cold War, the Soviets - led by sword-wielding Irina Spalko - are in search of a crystal skull which has supernatural powers related to a mystical Lost City of Gold. After being captured and then escaping from them, Indy is coerced to head to Peru at the behest of a young man whose friend - and Indy's colleague - Professor Oxley has been captured for his knowledge of the skull's whereabouts.
Fitzcarraldo is a dreamer who plans to build an opera house in Iquitos, in the Peruvian Amazon, so, in order to finance his project, he embarks on an epic adventure to collect rubber, a very profitable product, in a remote and unexplored region of the rainforest.
Der exzentrische Brian Sweeney Fitzcarraldo ist von der Idee besessen, mitten im unberührten Amazonas-Dschungel ein großes Opernhaus zu bauen. Von den Ersparnissen seiner Freundin, der Bordell-Besitzerin Molly, kauft Fitzcarraldo einen alten Flussdampfer. Um die gefährlichen Stromschnellen einer Flussmündung zu umgehen, entwickelt Fitzcarraldo einen atemberaubenden Plan: Hunderte von Indios sollen das riesige Schiff über eine unpassierbare Urwaldhöhe transportieren.