When Seth Brundle makes a huge scientific and technological breakthrough in teleportation, he decides to test it on himself. Unbeknownst to him, a common housefly manages to get inside the device and the two become one.
Members of an American scientific research outpost in Antarctica find themselves battling a parasitic alien organism capable of perfectly imitating its victims. They soon discover that this task will be harder than they thought, as they don't know which members of the team have already been assimilated and their paranoia threatens to tear them apart.
Martin Brundle, born of the human/fly, is adopted by his father's place of employment (Bartok Inc.) while the employees simply wait for his mutant chromosomes to come out of their dormant state.
Young sweethearts Billy and Kate move to the Big Apple, land jobs in a high-tech office park and soon reunite with the friendly and lovable Gizmo. But a series of accidents creates a whole new generation of Gremlins. The situation worsens when the devilish green creatures invade a top-secret laboratory and develop genetically altered powers, making them even harder to destroy!
'Hell' is the name of the hero of the story. He's a prisoner of the women who now run the USA after a nuclear/biological war. Results of the war are that mutants have evolved, and the human race is in danger of extinction due to infertility. Hell is given the task of helping in the rescue of a group of fertile women from the harem of the mutant leader (resembling a frog). Hell cannot escape since he has a bomb attached to his private parts which will detonate if he strays more than a few hundred yards from his guard.
A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.
Mulder and Scully, now taken off the FBI's X Files cases, must find a way to fight the shadowy elements of the government to find out the truth about a conspiracy that might mean the alien colonization of Earth.