When Dr. Henry Jones Sr. suddenly goes missing while pursuing the Holy Grail, eminent archaeologist Indiana must team up with Marcus Brody, Sallah and Elsa Schneider to follow in his father's footsteps and stop the Nazis from recovering the power of eternal life.
A group of strangers find themselves trapped in a maze-like prison. It soon becomes clear that each of them possesses the peculiar skills necessary to escape, if they don't wind up dead first.