When Seth Brundle makes a huge scientific and technological breakthrough in teleportation, he decides to test it on himself. Unbeknownst to him, a common housefly manages to get inside the device and the two become one.
Members of an American scientific research outpost in Antarctica find themselves battling a parasitic alien organism capable of perfectly imitating its victims. They soon discover that this task will be harder than they thought, as they don't know which members of the team have already been assimilated and their paranoia threatens to tear them apart.
Martin Brundle, born of the human/fly, is adopted by his father's place of employment (Bartok Inc.) while the employees simply wait for his mutant chromosomes to come out of their dormant state.