Just when George Banks has recovered from his daughter's wedding, he receives the news that she's pregnant ... and that George's wife is expecting too. He was planning on selling their home, but that's a plan that—like George—will have to change with the arrival of both a grandchild and a kid of his own.
A couple who cannot have children joins an in-vitro fertilization program. While she is with child, she finds strange occurrences happening within her body. The horror surrounding the child comes to light when the parents find that their child has been part of a mad experiment.
Arthur, that irrepressible drunk, tries to sober up and get a job. Meanwhile, Ralph Marolla is conniving to trick the hapless boozer into marrying his daughter so he can gain entrée to Arthur's $750 million fortune.
Novalee Nation is a 17-year-old Tennessee transient who has to grow up in a hurry when she's left pregnant and abandoned by her boyfriend on a roadside, and takes refuge in the friendly aisles of Wal-Mart. Eventually, some eccentric but kindly strangers 'adopt' Novalee and her infant daughter, helping them buck the odds and build a new life.